Blood inflammatory and endothelial markers in women with von Willebrand disease
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چکیده
منابع مشابه
Women with von Willebrand disease
The clinical presentation of VWD shows sex-related differences of symptoms. In women the most typical symptoms are menorrhagia, bleeding during and after delivery or abortion and bleeding in connection with caesarean section or gynaecological surgery. Menorrhagia is one of the most common symptoms presented to gynaecologists. In 7-20% of menorrhagia the underlying cause is VWD, in our cohort of...
متن کاملWomen with von Willebrand disease.
The clinical presentation of VWD shows sex-related differences of symptoms. In women the most typical symptoms are menorrhagia, bleeding during and after delivery or abortion and bleeding in connection with caesarean section or gynaecological surgery. Menorrhagia is one of the most common symptoms presented to gynaecologists. In 7-20% of menorrhagia the underlying cause is VWD, in our cohort of...
متن کاملscreening of von willebrand disease in iranian women with menorrhagia
conclusions the high prevalence of vwd among our patients was the same as other previous reports, suggesting low awareness about this disease and under diagnosis of mild cases. results mean age of our patients was 32.5 ± 10.6 years. the level of von willebrand factor in 22.5% and von willebrand activity in 19.6% of patients was abnormal. the prevalence of vwd among patients with menorrhagia was...
متن کاملChanges of von Willebrand Factor during Pregnancy in Women with and without von Willebrand Disease
Delivery in von Willebrand disease (VWD) represents a significant hemostatic challenge because of the variable pattern of changes observed during pregnancy of von Willebrand factor (VWF) and factor VIII (FVIII), the protein carried by VWF. Since a wide heterogeneity of phenotypes and of the underlying pathophysiological mechanisms is associated with this disorder, a prompt and careful evaluatio...
متن کاملPhenotypic correction of von Willebrand disease type 3 blood-derived endothelial cells with lentiviral vectors expressing von Willebrand factor.
Von Willebrand disease (VWD) is an inherited bleeding disorder, caused by quantitative (type 1 and 3) or qualitative (type 2) defects in von Willebrand factor (VWF). Gene therapy is an appealing strategy for treatment of VWD because it is caused by a single gene defect and because VWF is secreted into the circulation, obviating the need for targeting specific organs or tissues. However, develop...
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ژورنال
عنوان ژورنال: PLOS ONE
سال: 2019
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0210544